Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

Arya Sobhakumari; Laurie Love-Homan; Elise V. M. Fletcher; Sean M. Martin; Arlene D. Parsons; Douglas R. Spitz; C. Michael Knudson; Andrean L. Simons

doi:10.1371/journal.pone.0048175

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Peer-reviewed

Research Article

Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

Arya Sobhakumari,

Affiliations Department of Pathology, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Human Toxicology Program, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Laurie Love-Homan,

Affiliation Department of Pathology, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Elise V. M. Fletcher,

Affiliations Department of Pathology, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Human Toxicology Program, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Sean M. Martin,

Affiliation Department of Pathology, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Arlene D. Parsons,

Affiliation Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Douglas R. Spitz,

Affiliations Interdisciplinary Human Toxicology Program, The University of Iowa, Iowa City, Iowa, United States of America, Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, United States of America, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa, United States of America
⨯
C. Michael Knudson,

Affiliations Department of Pathology, The University of Iowa, Iowa City, Iowa, United States of America, Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, United States of America, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Andrean L. Simons

* E-mail: andrean-simons@uiowa.edu

Affiliations Department of Pathology, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Human Toxicology Program, The University of Iowa, Iowa City, Iowa, United States of America, Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, United States of America, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa, United States of America
⨯

Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

Arya Sobhakumari,
Laurie Love-Homan,
Elise V. M. Fletcher,
Sean M. Martin,
Arlene D. Parsons,
Douglas R. Spitz,
C. Michael Knudson,
Andrean L. Simons

Published: October 31, 2012
https://doi.org/10.1371/journal.pone.0048175

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Glutathione
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Cancers and neoplasms
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Cancer treatment
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Apoptosis
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Oxidative stress
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Cell metabolism
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Head and neck squamous cell carcinoma
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Necrosis
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