Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice

Natalie C. Sadler; Thomas E. Angel; Michael P. Lewis; LeeAnna M. Pederson; Lacie M. Chauvigné-Hines; Susan D. Wiedner; Erika M. Zink; Richard D. Smith; Aaron T. Wright

doi:10.1371/journal.pone.0047996

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Peer-reviewed

Research Article

Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice

Natalie C. Sadler ,

Contributed equally to this work with: Natalie C. Sadler, Thomas E. Angel

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Thomas E. Angel ,

Contributed equally to this work with: Natalie C. Sadler, Thomas E. Angel

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Michael P. Lewis,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
LeeAnna M. Pederson,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Lacie M. Chauvigné-Hines,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Susan D. Wiedner,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Erika M. Zink,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Richard D. Smith,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Aaron T. Wright

* E-mail: aaron.wright@pnnl.gov

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯

Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice

Natalie C. Sadler,
Thomas E. Angel,
Michael P. Lewis,
LeeAnna M. Pederson,
Lacie M. Chauvigné-Hines,
Susan D. Wiedner,
Erika M. Zink,
Richard D. Smith,
Aaron T. Wright

Published: October 24, 2012
https://doi.org/10.1371/journal.pone.0047996

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Mitochondria
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Skeletal muscles
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Diet
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Oxidative phosphorylation
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Lipid metabolism
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Citric acid cycle
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Obesity
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