Mucosal Immunization with Live Attenuated Francisella novicida U112ΔiglB Protects against Pulmonary F. tularensis SCHU S4 in the Fischer 344 Rat Model

Aimee L. Signarovitz; Heather J. Ray; Jieh-Juen Yu; M. N. Guentzel; James P. Chambers; Karl E. Klose; Bernard P. Arulanandam

doi:10.1371/journal.pone.0047639

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Research Article

Mucosal Immunization with Live Attenuated Francisella novicida U112ΔiglB Protects against Pulmonary F. tularensis SCHU S4 in the Fischer 344 Rat Model

Aimee L. Signarovitz,

Affiliations South Texas Center for Emerging Infectious Disease and Center of Excellence in Infection Genomics, University of Texas at San Antonio, San Antonio, Texas, United States of America, Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Heather J. Ray,

Affiliation South Texas Center for Emerging Infectious Disease and Center of Excellence in Infection Genomics, University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯
Jieh-Juen Yu,

Affiliation South Texas Center for Emerging Infectious Disease and Center of Excellence in Infection Genomics, University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯
M. N. Guentzel,

Affiliation South Texas Center for Emerging Infectious Disease and Center of Excellence in Infection Genomics, University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯
James P. Chambers,

Affiliation South Texas Center for Emerging Infectious Disease and Center of Excellence in Infection Genomics, University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯
Karl E. Klose,

Affiliation South Texas Center for Emerging Infectious Disease and Center of Excellence in Infection Genomics, University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯
Bernard P. Arulanandam

* E-mail: bernard.arulanandam@utsa.edu

Affiliation South Texas Center for Emerging Infectious Disease and Center of Excellence in Infection Genomics, University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯

Mucosal Immunization with Live Attenuated Francisella novicida U112ΔiglB Protects against Pulmonary F. tularensis SCHU S4 in the Fischer 344 Rat Model

Aimee L. Signarovitz,
Heather J. Ray,
Jieh-Juen Yu,
M. N. Guentzel,
James P. Chambers,
Karl E. Klose,
Bernard P. Arulanandam

Published: October 30, 2012
https://doi.org/10.1371/journal.pone.0047639

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Francisella tularensis
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