Hyperglycaemia Exacerbates Choroidal Neovascularisation in Mice via the Oxidative Stress-Induced Activation of STAT3 Signalling in RPE Cells

Xia Li; Yan Cai; Yu-Sheng Wang; Yuan-Yuan Shi; Wei Hou; Chun-Sheng Xu; Hai-Yan Wang; Zi Ye; Li-Bo Yao; Jian Zhang

doi:10.1371/journal.pone.0047600

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Open Access

Peer-reviewed

Research Article

Hyperglycaemia Exacerbates Choroidal Neovascularisation in Mice via the Oxidative Stress-Induced Activation of STAT3 Signalling in RPE Cells

Xia Li ,

Contributed equally to this work with: Xia Li, Yan Cai

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Yan Cai ,

Contributed equally to this work with: Xia Li, Yan Cai

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Yu-Sheng Wang ,

* E-mail: wangys003@126.com (YSW); biozhangj@yahoo.com.cn (JZ)

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Yuan-Yuan Shi,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Wei Hou,

Affiliation Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Chun-Sheng Xu,

Affiliation State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Hai-Yan Wang,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Zi Ye,

Affiliation Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Li-Bo Yao,

Affiliation State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯
Jian Zhang

* E-mail: wangys003@126.com (YSW); biozhangj@yahoo.com.cn (JZ)

Affiliation State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China
⨯

Hyperglycaemia Exacerbates Choroidal Neovascularisation in Mice via the Oxidative Stress-Induced Activation of STAT3 Signalling in RPE Cells

Xia Li,
Yan Cai,
Yu-Sheng Wang,
Yuan-Yuan Shi,
Wei Hou,
Chun-Sheng Xu,
Hai-Yan Wang,
Zi Ye,
Li-Bo Yao,
Jian Zhang

Published: October 19, 2012
https://doi.org/10.1371/journal.pone.0047600

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