Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene

Xiumei Zhou; Guoliang Xie; Shibing Wang; Yigang Wang; Kangjian Zhang; Shu Zheng; Liang Chu; Lianli Xiao; Yuemei Yu; Yue Zhang; Xinyuan Liu

doi:10.1371/journal.pone.0047566

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Open Access

Peer-reviewed

Research Article

Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene

Xiumei Zhou ,

Contributed equally to this work with: Xiumei Zhou, Guoliang Xie

Affiliation Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Guoliang Xie ,

Contributed equally to this work with: Xiumei Zhou, Guoliang Xie

Affiliation Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Shibing Wang,

Affiliation Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Yigang Wang,

Affiliation Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Kangjian Zhang,

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Shu Zheng,

Affiliation Cancer Institute, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Liang Chu,

Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Lianli Xiao,

Affiliation Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Yuemei Yu,

Affiliation Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Yue Zhang,

Affiliation Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Xinyuan Liu

* E-mail: xyliu@sibs.ac.cn

Affiliations Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou, China, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯

Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene

Xiumei Zhou,
Guoliang Xie,
Shibing Wang,
Yigang Wang,
Kangjian Zhang,
Shu Zheng,
Liang Chu,
Lianli Xiao,
Yuemei Yu,
Yue Zhang

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0047566

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