APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

Angelo A. Cardoso; Yanlin Jiang; Meihua Luo; April M. Reed; Safi Shahda; Ying He; Anirban Maitra; Mark R. Kelley; Melissa L. Fishel

doi:10.1371/journal.pone.0047462

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Open Access

Peer-reviewed

Research Article

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

Angelo A. Cardoso,

Affiliation Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Yanlin Jiang,

Affiliation Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States of America
⨯
Meihua Luo,

Affiliation Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States of America
⨯
April M. Reed,

Affiliation Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States of America
⨯
Safi Shahda,

Affiliation Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Ying He,

Affiliation Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States of America
⨯
Anirban Maitra,

Affiliation Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Mark R. Kelley,

Affiliations Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States of America, Department of Pharmacology and Toxicology, Indiana University of School of Medicine, Indianapolis, Indiana, United States of America, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Melissa L. Fishel

* E-mail: mfishel@iupui.edu

Affiliations Section of Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States of America, Department of Pharmacology and Toxicology, Indiana University of School of Medicine, Indianapolis, Indiana, United States of America
⨯

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

Angelo A. Cardoso,
Yanlin Jiang,
Meihua Luo,
April M. Reed,
Safi Shahda,
Ying He,
Anirban Maitra,
Mark R. Kelley,
Melissa L. Fishel

Published: October 19, 2012
https://doi.org/10.1371/journal.pone.0047462

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Oxidation-reduction reactions
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Redox signaling
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STAT signaling
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DNA binding assay
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Pancreatic cancer
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Transcription factors
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Electrophoretic mobility shift assay
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Transcriptional control
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