Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic β-Cells

Open Access

Peer-reviewed

Research Article

Kyota Aoyagi,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Mica Ohara-Imaizumi,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Chiyono Nishiwaki,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Yoko Nakamichi,

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯
Kohjiro Ueki,

Affiliation Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
⨯
Takashi Kadowaki,

Affiliation Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
⨯
Shinya Nagamatsu

* E-mail: shinya@ks.kyorin-u.ac.jp

Affiliation Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
⨯

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Insulin secretion
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Insulin
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Glucose
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Transfection
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Cell fusion
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Membrane fusion
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Secretion
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Cell membranes
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