Spironolactone Rescues Dot1a-Af9-Mediated Repression of Endothelin-1 and Improves Kidney Injury in Streptozotocin-Induced Diabetic Rats

Qiaoling Zhou; Kanghan Liu; Hongyu Wu; Lihe Chen; Veeraragoo Pouranan; Mingxia Yuan; Zhou Xiao; Weisheng Peng; Ao Xiang; Rong Tang; Wenzheng Zhang

doi:10.1371/journal.pone.0047360

Loading metrics

Open Access

Peer-reviewed

Research Article

Spironolactone Rescues Dot1a-Af9-Mediated Repression of Endothelin-1 and Improves Kidney Injury in Streptozotocin-Induced Diabetic Rats

Qiaoling Zhou ,

* E-mail: zhouqling@yahoo.com.cn (QZ); wenzheng.zhang@uth.tmc.edu (WZ)

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Kanghan Liu,

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Hongyu Wu,

Affiliation Department of Internal Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America
⨯
Lihe Chen,

Affiliation Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯
Veeraragoo Pouranan,

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Mingxia Yuan,

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Zhou Xiao,

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Weisheng Peng,

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Ao Xiang,

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Rong Tang,

Affiliation Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China
⨯
Wenzheng Zhang

* E-mail: zhouqling@yahoo.com.cn (QZ); wenzheng.zhang@uth.tmc.edu (WZ)

Affiliations Department of Internal Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯

Spironolactone Rescues Dot1a-Af9-Mediated Repression of Endothelin-1 and Improves Kidney Injury in Streptozotocin-Induced Diabetic Rats

Qiaoling Zhou,
Kanghan Liu,
Hongyu Wu,
Lihe Chen,
Veeraragoo Pouranan,
Mingxia Yuan,
Zhou Xiao,
Weisheng Peng,
Ao Xiang,
Rong Tang

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0047360

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Aldosterone
Is the Subject Area "Aldosterone" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Cell binding
Is the Subject Area "Cell binding" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.