In Situ Mass Spectrometry Imaging and Ex Vivo Characterization of Renal Crystalline Deposits Induced in Multiple Preclinical Drug Toxicology Studies

• Anna Nilsson ,

  Contributed equally to this work with: Anna Nilsson, Benita Forngren

  * E-mail: anna.nilsson@farmbio.uu.se

  Affiliation Medical Mass Spectrometry, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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• Benita Forngren ,

  Contributed equally to this work with: Anna Nilsson, Benita Forngren

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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• Sivert Bjurström,

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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• Richard J. A. Goodwin,

  Affiliation Global Distribution Imaging, DMPK IM, AstraZeneca R&D, Södertälje, Sweden

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• Elisa Basmaci,

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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• Ingela Gustafsson,

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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• Anita Annas,

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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• Dennis Hellgren,

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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• Alexander Svanhagen,

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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• Per E. Andrén ,

  ¶Contributed equally to supervision of this work.

  Affiliation Medical Mass Spectrometry, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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• Johan Lindberg

  ¶Contributed equally to supervision of this work.

  Affiliation Safety Assessment, AstraZeneca R&D, Södertälje, Sweden

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