Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression

Xiuxiu Lv; Xiaohui Yu; Yiyang Wang; Faqiang Wang; Hongmei Li; Yanping Wang; Daxiang Lu; Renbin Qi; Huadong Wang

doi:10.1371/journal.pone.0047351

Loading metrics

Open Access

Peer-reviewed

Research Article

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression

Xiuxiu Lv,

Affiliation Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Xiaohui Yu,

Affiliation Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Yiyang Wang,

Affiliation Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Faqiang Wang,

Affiliation Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Hongmei Li,

Affiliation Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Yanping Wang,

Affiliation Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Daxiang Lu,

Affiliations Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Renbin Qi,

Affiliations Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Huadong Wang

* E-mail: owanghd@jnu.edu.cn

Affiliations Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University, Guangzhou, Guangdong, China
⨯

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression

Xiuxiu Lv,
Xiaohui Yu,
Yiyang Wang,
Faqiang Wang,
Hongmei Li,
Yanping Wang,
Daxiang Lu,
Renbin Qi,
Huadong Wang

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0047351

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cardiomyocytes
Is the Subject Area "Cardiomyocytes" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Membrane potential
Is the Subject Area "Membrane potential" applicable to this article?

Thanks for your feedback.
Mitochondrial membrane
Is the Subject Area "Mitochondrial membrane" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Myocardium
Is the Subject Area "Myocardium" applicable to this article?

Thanks for your feedback.