Accurate Simulation and Detection of Coevolution Signals in Multiple Sequence Alignments

Open Access

Peer-reviewed

Research Article

Sharon H. Ackerman,

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
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Elisabeth R. Tillier,

Affiliation Department of Medical Biophysics, University of Toronto, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
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Domenico L. Gatti

* E-mail: dgatti@med.wayne.edu

Affiliations Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
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Coevolution
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Covariance
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Entropy
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Sequence alignment
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Protein structure
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Point mutation
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Algorithms
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Biochemical simulations
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