Argonaute 2 Complexes Selectively Protect the Circulating MicroRNAs in Cell-Secreted Microvesicles

Limin Li; Dihan Zhu; Lei Huang; Jing Zhang; Zhen Bian; Xi Chen; Yuan Liu; Chen-Yu Zhang; Ke Zen

doi:10.1371/journal.pone.0046957

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Open Access

Peer-reviewed

Research Article

Argonaute 2 Complexes Selectively Protect the Circulating MicroRNAs in Cell-Secreted Microvesicles

Limin Li,

Affiliation Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Dihan Zhu,

Affiliation Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Lei Huang,

Affiliation Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Jing Zhang,

Affiliation Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Zhen Bian,

Affiliations Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China, CMBP, Department of Biology, Georgia State University, Atlanta, Georgia, United States of America
⨯
Xi Chen,

Affiliation Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Yuan Liu,

Affiliation CMBP, Department of Biology, Georgia State University, Atlanta, Georgia, United States of America
⨯
Chen-Yu Zhang ,

* E-mail: cyzhang@nju.edu.cn (C-YZ); kzen@nju.edu.cn (KZ)

Affiliation Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯
Ke Zen

* E-mail: cyzhang@nju.edu.cn (C-YZ); kzen@nju.edu.cn (KZ)

Affiliation Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
⨯

Argonaute 2 Complexes Selectively Protect the Circulating MicroRNAs in Cell-Secreted Microvesicles

Limin Li,
Dihan Zhu,
Lei Huang,
Jing Zhang,
Zhen Bian,
Xi Chen,
Yuan Liu,
Chen-Yu Zhang,
Ke Zen

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0046957

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