Cysteine 904 Is Required for Maximal Insulin Degrading Enzyme Activity and Polyanion Activation

Open Access

Peer-reviewed

Research Article

Eun Suk Song,

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Manana Melikishvili,

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Michael G. Fried,

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Maria A. Juliano,

Affiliation Department of Biophysics, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Rua Tres de Maio, Sao Paulo, Brazil
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Luiz Juliano,

Affiliation Department of Biophysics, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Rua Tres de Maio, Sao Paulo, Brazil
⨯
David W. Rodgers,

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Louis B. Hersh

* E-mail: lhersh@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
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Cysteine
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Insulin
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Serine
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Enzyme structure
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Dimers
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Enzymes
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Hydrolysis
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Hydrogen bonding
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