Immunogenicity and Efficacy of Intramuscular Replication-Defective and Subunit Vaccines against Herpes Simplex Virus Type 2 in the Mouse Genital Model

Simon Delagrave; Hector Hernandez; Changhong Zhou; John F. Hamberger; Sophia T. Mundle; John Catalan; Simge Baloglu; Stephen F. Anderson; Joshua M. DiNapoli; Patricia Londoño-Hayes; Mark Parrington; Jeffrey Almond; Harry Kleanthous

doi:10.1371/journal.pone.0046714

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Open Access

Peer-reviewed

Research Article

Immunogenicity and Efficacy of Intramuscular Replication-Defective and Subunit Vaccines against Herpes Simplex Virus Type 2 in the Mouse Genital Model

Simon Delagrave ,

* E-mail: simon.delagrave@sanofipasteur.com

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Hector Hernandez,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Changhong Zhou,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
John F. Hamberger,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Sophia T. Mundle,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
John Catalan,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Simge Baloglu,

Current address: Momenta Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Stephen F. Anderson,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Joshua M. DiNapoli,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Patricia Londoño-Hayes,

Current address: Sanofi Pasteur, Non-Clinical Product Performance, Marcy l'Etoile, France

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Mark Parrington,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Jeffrey Almond,

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯
Harry Kleanthous

Affiliation Sanofi Pasteur, Discovery North America, Cambridge, Massachusetts, United States of America
⨯

Immunogenicity and Efficacy of Intramuscular Replication-Defective and Subunit Vaccines against Herpes Simplex Virus Type 2 in the Mouse Genital Model

Simon Delagrave,
Hector Hernandez,
Changhong Zhou,
John F. Hamberger,
Sophia T. Mundle,
John Catalan,
Simge Baloglu,
Stephen F. Anderson,
Joshua M. DiNapoli,
Patricia Londoño-Hayes

Published: October 11, 2012
https://doi.org/10.1371/journal.pone.0046714

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