Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

Open Access

Peer-reviewed

Research Article

Christophe J. De Saedeleer,

Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium
⨯
Tamara Copetti,

Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium
⨯
Paolo E. Porporato,

Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium
⨯
Julien Verrax,

Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium
⨯
Olivier Feron ,

Contributed equally to this work with: Olivier Feron, Pierre Sonveaux

Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium
⨯
Pierre Sonveaux

Contributed equally to this work with: Olivier Feron, Pierre Sonveaux

* E-mail: pierre.sonveaux@uclouvain.be

Affiliation Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium
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Protein expression
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Glycolysis
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Malignant tumors
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Cancers and neoplasms
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Hypoxia
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Pyruvate
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Cell metabolism
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Small interfering RNA
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