Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Johanna S. Blees; Heidi R. Bokesch; Daniela Rübsamen; Kathrin Schulz; Larissa Milke; Magdalena M. Bajer; Kirk R. Gustafson; Curtis J. Henrich; James B. McMahon; Nancy H. Colburn; Tobias Schmid; Bernhard Brüne

doi:10.1371/journal.pone.0046567

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Peer-reviewed

Research Article

Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Johanna S. Blees,

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
⨯
Heidi R. Bokesch,

Affiliations Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Daniela Rübsamen,

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
⨯
Kathrin Schulz,

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
⨯
Larissa Milke,

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
⨯
Magdalena M. Bajer,

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
⨯
Kirk R. Gustafson,

Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Curtis J. Henrich,

Affiliations Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
James B. McMahon,

Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Nancy H. Colburn,

Affiliation Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Tobias Schmid ,

Contributed equally to this work with: Tobias Schmid, Bernhard Brüne

* E-mail: T.Schmid@biochem.uni-frankfurt.de

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
⨯
Bernhard Brüne

Contributed equally to this work with: Tobias Schmid, Bernhard Brüne

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany
⨯

Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Johanna S. Blees,
Heidi R. Bokesch,
Daniela Rübsamen,
Kathrin Schulz,
Larissa Milke,
Magdalena M. Bajer,
Kirk R. Gustafson,
Curtis J. Henrich,
James B. McMahon,
Nancy H. Colburn

Published: October 2, 2012
https://doi.org/10.1371/journal.pone.0046567

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