Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells

Marica Vaapil; Karolina Helczynska; René Villadsen; Ole W. Petersen; Elisabet Johansson; Siv Beckman; Christer Larsson; Sven Påhlman; Annika Jögi

doi:10.1371/journal.pone.0046543

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Open Access

Peer-reviewed

Research Article

Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells

Marica Vaapil,

Affiliations Department of Laboratory Medicine, Center for Molecular Pathology, Skåne University Hospital Malmö, Malmö, Sweden, CREATE Health, Lund University, Lund, Sweden
⨯
Karolina Helczynska,

Affiliations Department of Laboratory Medicine, Center for Molecular Pathology, Skåne University Hospital Malmö, Malmö, Sweden, CREATE Health, Lund University, Lund, Sweden, Department of Surgery, Skåne University Hospital, Malmö, Sweden
⨯
René Villadsen,

Affiliation Department of Cellular and Molecular Medicine, Centre for Biological Disease Analysis, and The Danish Stem Cell Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Ole W. Petersen,

Affiliation Department of Cellular and Molecular Medicine, Centre for Biological Disease Analysis, and The Danish Stem Cell Centre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Elisabet Johansson,

Affiliations Department of Laboratory Medicine, Center for Molecular Pathology, Skåne University Hospital Malmö, Malmö, Sweden, CREATE Health, Lund University, Lund, Sweden
⨯
Siv Beckman,

Affiliations Department of Laboratory Medicine, Center for Molecular Pathology, Skåne University Hospital Malmö, Malmö, Sweden, CREATE Health, Lund University, Lund, Sweden
⨯
Christer Larsson,

Affiliation Department of Laboratory Medicine, Center for Molecular Pathology, Skåne University Hospital Malmö, Malmö, Sweden
⨯
Sven Påhlman,

Affiliations Department of Laboratory Medicine, Center for Molecular Pathology, Skåne University Hospital Malmö, Malmö, Sweden, CREATE Health, Lund University, Lund, Sweden
⨯
Annika Jögi

* E-mail: annika.jogi@med.lu.se

Affiliations Department of Laboratory Medicine, Center for Molecular Pathology, Skåne University Hospital Malmö, Malmö, Sweden, CREATE Health, Lund University, Lund, Sweden
⨯

Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells

Marica Vaapil,
Karolina Helczynska,
René Villadsen,
Ole W. Petersen,
Elisabet Johansson,
Siv Beckman,
Christer Larsson,
Sven Påhlman,
Annika Jögi

Published: September 28, 2012
https://doi.org/10.1371/journal.pone.0046543

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Hypoxia
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Epithelial cells
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Cell differentiation
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Breast cancer
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Medical hypoxia
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Organoids
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Acinar morphogenesis
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Oxygen
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