Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation

Open Access

Peer-reviewed

Research Article

Claire E. Turner,

Affiliation Department of Infectious Diseases & Immunity, Imperial College London, London, United Kingdom
⨯
Mary Sommerlad,

Affiliation Department of Infectious Diseases & Immunity, Imperial College London, London, United Kingdom
⨯
Karen McGregor,

Affiliation Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
⨯
Frances J. Davies,

Affiliation Department of Infectious Diseases & Immunity, Imperial College London, London, United Kingdom
⨯
Bruno Pichon,

Affiliation Respiratory and Systemic Infection Laboratory, The Health Protection Agency Centre for Infections, London, United Kingdom
⨯
Deborah L. W. Chong,

Affiliation Department of Infectious Diseases & Immunity, Imperial College London, London, United Kingdom
⨯
Leili Farzaneh,

Affiliation Department of Infectious Diseases & Immunity, Imperial College London, London, United Kingdom
⨯
Matthew T. G. Holden,

Affiliation Pathogen Genomics, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom
⨯
Brian G. Spratt,

Affiliation Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
⨯
Androulla Efstratiou,

Affiliation Respiratory and Systemic Infection Laboratory, The Health Protection Agency Centre for Infections, London, United Kingdom
⨯
Shiranee Sriskandan

* E-mail: s.sriskandan@imperial.ac.uk

Affiliation Department of Infectious Diseases & Immunity, Imperial College London, London, United Kingdom
⨯

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Streptococcus pyogenes
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Cytokines
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Toxic shock syndrome
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Tonsils
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Streptococcal infections
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Deletion mutation
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T cells
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Gene disruption
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