Subdominant Antigens in Bacterial Vaccines: AM779 Is Subdominant in the Anaplasma marginale Outer Membrane Vaccine but Does Not Associate with Protective Immunity

Saleh M. Albarrak; Wendy C. Brown; Susan M. Noh; Kathryn E. Reif; Glen A. Scoles; Joshua E. Turse; Junzo Norimine; Massaro W. Ueti; Guy H. Palmer

doi:10.1371/journal.pone.0046372

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Research Article

Subdominant Antigens in Bacterial Vaccines: AM779 Is Subdominant in the Anaplasma marginale Outer Membrane Vaccine but Does Not Associate with Protective Immunity

Saleh M. Albarrak,

Affiliation Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, United States of America
⨯
Wendy C. Brown,

Affiliation Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, United States of America
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Susan M. Noh,

Affiliation Animal Diseases Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, Washington, United States of America
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Kathryn E. Reif,

Affiliations Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, United States of America, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, United States of America
⨯
Glen A. Scoles,

Affiliation Animal Diseases Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, Washington, United States of America
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Joshua E. Turse,

Affiliation Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, United States of America
⨯
Junzo Norimine,

Affiliation Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, United States of America
⨯
Massaro W. Ueti,

Affiliation Animal Diseases Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, Washington, United States of America
⨯
Guy H. Palmer

* E-mail: gpalmer@vetmed.wsu.edu

Affiliations Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, United States of America, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, United States of America
⨯

Subdominant Antigens in Bacterial Vaccines: AM779 Is Subdominant in the Anaplasma marginale Outer Membrane Vaccine but Does Not Associate with Protective Immunity

Saleh M. Albarrak,
Wendy C. Brown,
Susan M. Noh,
Kathryn E. Reif,
Glen A. Scoles,
Joshua E. Turse,
Junzo Norimine,
Massaro W. Ueti,
Guy H. Palmer

Published: September 28, 2012
https://doi.org/10.1371/journal.pone.0046372

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Antigens
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Outer membrane proteins
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Vaccination and immunization
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Immune response
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Vaccine development
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Immunologic adjuvants
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Membrane protein complexes
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T cells
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