SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

Hongying Yang; Wei Zhang; Heng Pan; Heidi G. Feldser; Elden Lainez; Christine Miller; Stewart Leung; Zhong Zhong; Huizhen Zhao; Sharon Sweitzer; Thomas Considine; Thomas Riera; Vipin Suri; Brian White; James L. Ellis; George P. Vlasuk; Christine Loh

doi:10.1371/journal.pone.0046364

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Open Access

Peer-reviewed

Research Article

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

Hongying Yang ,

* E-mail: Hongying.2.yang@gsk.com

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
Wei Zhang,

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China
⨯
Heng Pan,

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China
⨯
Heidi G. Feldser,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
Elden Lainez,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
Christine Miller,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
Stewart Leung,

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China
⨯
Zhong Zhong,

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China
⨯
Huizhen Zhao,

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Sharon Sweitzer,

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
⨯
Thomas Considine,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
Thomas Riera,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
Vipin Suri,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
Brian White,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
James L. Ellis,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
George P. Vlasuk,

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
[ ... ],
Christine Loh

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America
⨯
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SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

Hongying Yang,
Wei Zhang,
Heng Pan,
Heidi G. Feldser,
Elden Lainez,
Christine Miller,
Stewart Leung,
Zhong Zhong,
Huizhen Zhao,
Sharon Sweitzer

Published: September 28, 2012
https://doi.org/10.1371/journal.pone.0046364

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