Inhibition of BDNF in Multiple Myeloma Blocks Osteoclastogenesis via Down-Regulated Stroma-Derived RANKL Expression Both In Vitro and In Vivo

Li-Sha Ai; Chun-Yan Sun; Lu Zhang; Shun-Chang Zhou; Zhang-Bo Chu; You Qin; Ya-Dan Wang; Wei Zeng; Han Yan; Tao Guo; Lei Chen; Di Yang; Yu Hu

doi:10.1371/journal.pone.0046287

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Open Access

Peer-reviewed

Research Article

Inhibition of BDNF in Multiple Myeloma Blocks Osteoclastogenesis via Down-Regulated Stroma-Derived RANKL Expression Both In Vitro and In Vivo

Li-Sha Ai,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Chun-Yan Sun,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Lu Zhang,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Shun-Chang Zhou,

Affiliation Deparment of Experimental Animals, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Zhang-Bo Chu,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
You Qin,

Affiliation Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Ya-Dan Wang,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Wei Zeng,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Han Yan,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Tao Guo,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Lei Chen,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Di Yang,

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yu Hu

* E-mail: dr_huyu@126.com

Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯

Inhibition of BDNF in Multiple Myeloma Blocks Osteoclastogenesis via Down-Regulated Stroma-Derived RANKL Expression Both In Vitro and In Vivo

Li-Sha Ai,
Chun-Yan Sun,
Lu Zhang,
Shun-Chang Zhou,
Zhang-Bo Chu,
You Qin,
Ya-Dan Wang,
Wei Zeng,
Han Yan,
Tao Guo

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0046287

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Osteoclasts
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Cancers and neoplasms
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