Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

Wei Cui; Zaijun Zhang; Wenming Li; Shinghung Mak; Shengquan Hu; Huan Zhang; Shuai Yuan; Jianhui Rong; Tony Chunglit Choi; Simon M. Y. Lee; Yifan Han

doi:10.1371/journal.pone.0046253

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Open Access

Peer-reviewed

Research Article

Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

Wei Cui ,

Contributed equally to this work with: Wei Cui, Zaijun Zhang

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯
Zaijun Zhang ,

Contributed equally to this work with: Wei Cui, Zaijun Zhang

Affiliations State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China, Institute of New Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guang Zhou, Guangdong, China
⨯
Wenming Li,

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯
Shinghung Mak,

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯
Shengquan Hu,

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯
Huan Zhang,

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯
Shuai Yuan,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
⨯
Jianhui Rong,

Affiliation School of Chinese Medicine, the University of Hong Kong, Hong Kong, China
⨯
Tony Chunglit Choi,

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯
Simon M. Y. Lee ,

* E-mail: bcyfhan@polyu.edu.hk (YH); SimonLee@umac.mo (SMYL)

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
⨯
Yifan Han

* E-mail: bcyfhan@polyu.edu.hk (YH); SimonLee@umac.mo (SMYL)

Affiliation Department of Applied Biology and Chemical Technology, Institute of Modern Medicine, The Hong Kong Polytechnic University, Hong Kong, China
⨯

Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

Wei Cui,
Zaijun Zhang,
Wenming Li,
Shinghung Mak,
Shengquan Hu,
Huan Zhang,
Shuai Yuan,
Jianhui Rong,
Tony Chunglit Choi,
Simon M. Y. Lee

Published: September 25, 2012
https://doi.org/10.1371/journal.pone.0046253

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