Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion

Martin Heni; Caroline Ketterer; Robert Wagner; Katarzyna Linder; Anja Böhm; Silke A. Herzberg-Schäfer; Fausto Machicao; Klaus-Peter Knoch; Andreas Fritsche; Harald Staiger; Hans-Ulrich Häring; Michele Solimena

doi:10.1371/journal.pone.0046154

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Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion

Martin Heni,

Affiliation Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Caroline Ketterer,

Affiliation Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Robert Wagner,

Affiliation Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Katarzyna Linder,

Affiliation Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Anja Böhm,

Affiliation Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Silke A. Herzberg-Schäfer,

Affiliation Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Fausto Machicao,

Affiliations Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Partner in the German Center for Diabetes Research (DZD), Tübingen, Germany
⨯
Klaus-Peter Knoch,

Affiliation Molecular Diabetology, Paul Langerhans Institute Dresden, University Hospital and Medical School Carl Gustav Carus, Dresden University of Technology, Partner in the German Center for Diabetes Research (DZD), Dresden, Germany
⨯
Andreas Fritsche,

Affiliations Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Partner in the German Center for Diabetes Research (DZD), Tübingen, Germany, Department of Internal Medicine, Nutritional and Preventive Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
⨯
Harald Staiger,

Affiliations Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Partner in the German Center for Diabetes Research (DZD), Tübingen, Germany
⨯
Hans-Ulrich Häring ,

* E-mail: hans-ulrich.haering@med.uni-tuebingen.de

Affiliations Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Partner in the German Center for Diabetes Research (DZD), Tübingen, Germany
⨯
Michele Solimena

Affiliation Molecular Diabetology, Paul Langerhans Institute Dresden, University Hospital and Medical School Carl Gustav Carus, Dresden University of Technology, Partner in the German Center for Diabetes Research (DZD), Dresden, Germany
⨯

Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion

Martin Heni,
Caroline Ketterer,
Robert Wagner,
Katarzyna Linder,
Anja Böhm,
Silke A. Herzberg-Schäfer,
Fausto Machicao,
Klaus-Peter Knoch,
Andreas Fritsche,
Harald Staiger

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0046154

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Single nucleotide polymorphisms
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