Inhibition of Hepatitis B Virus and Induction of Hepatoma Cell Apoptosis by ASGPR-Directed Delivery of shRNAs

Jingwei Ma; Chunmei Huang; Xinxin Yao; Chuan Shi; Lifang Sun; Lu Yuan; Ping Lei; Huifen Zhu; Hongbo Liu; Xiongwen Wu; Qin Ning; Chun Zhou; Guanxin Shen

doi:10.1371/journal.pone.0046096

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Open Access

Peer-reviewed

Research Article

Inhibition of Hepatitis B Virus and Induction of Hepatoma Cell Apoptosis by ASGPR-Directed Delivery of shRNAs

Jingwei Ma ,

Contributed equally to this work with: Jingwei Ma, Chunmei Huang

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Chunmei Huang ,

Contributed equally to this work with: Jingwei Ma, Chunmei Huang

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Xinxin Yao,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Chuan Shi,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Lifang Sun,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Lu Yuan,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Ping Lei,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Huifen Zhu,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Hongbo Liu,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Xiongwen Wu,

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Qin Ning,

Affiliation Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯
Chun Zhou ,

* E-mail: cz2132@columbia.edu (CZ); guanxin_shen@yahoo.com.cn (GS)

Affiliation Department of Environmental Health Sciences, Columbia University, New York, New York, United States of America
⨯
Guanxin Shen

* E-mail: cz2132@columbia.edu (CZ); guanxin_shen@yahoo.com.cn (GS)

Affiliation Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
⨯

Inhibition of Hepatitis B Virus and Induction of Hepatoma Cell Apoptosis by ASGPR-Directed Delivery of shRNAs

Jingwei Ma,
Chunmei Huang,
Xinxin Yao,
Chuan Shi,
Lifang Sun,
Lu Yuan,
Ping Lei,
Huifen Zhu,
Hongbo Liu,
Xiongwen Wu

Published: October 19, 2012
https://doi.org/10.1371/journal.pone.0046096

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Transfection
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Apoptosis
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Hepatitis B virus
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Mouse models
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Hepatoma cells
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Hepatocytes
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Hepatocellular carcinoma
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Polymerase chain reaction
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