Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells

Antonio Marcilla; María Trelis; Alba Cortés; Javier Sotillo; Fernando Cantalapiedra; María Teresa Minguez; María Luz Valero; Manuel Mateo Sánchez del Pino; Carla Muñoz-Antoli; Rafael Toledo; Dolores Bernal

doi:10.1371/journal.pone.0045974

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Peer-reviewed

Research Article

Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells

Antonio Marcilla ,

* E-mail: antonio.marcilla@uv.es

Affiliation Área de Parasitología, Departamento de Biología Celular y Parasitología, Universitat de València, Burjassot, Valencia, Spain
⨯
María Trelis,

Affiliation Área de Parasitología, Departamento de Biología Celular y Parasitología, Universitat de València, Burjassot, Valencia, Spain
⨯
Alba Cortés,

Affiliation Área de Parasitología, Departamento de Biología Celular y Parasitología, Universitat de València, Burjassot, Valencia, Spain
⨯
Javier Sotillo,

Affiliation Área de Parasitología, Departamento de Biología Celular y Parasitología, Universitat de València, Burjassot, Valencia, Spain
⨯
Fernando Cantalapiedra,

Affiliation Área de Parasitología, Departamento de Biología Celular y Parasitología, Universitat de València, Burjassot, Valencia, Spain
⨯
María Teresa Minguez,

Affiliation Servicios Centrales de Soporte a la Investigación Experimental (SCSIE) de Universitat de València, Burjassot, Valencia, Spain
⨯
María Luz Valero,

Affiliations Servicios Centrales de Soporte a la Investigación Experimental (SCSIE) de Universitat de València, Burjassot, Valencia, Spain, Servicio de Proteómica, Centro de Investigación “Príncipe Felipe”, Valencia, Spain
⨯
Manuel Mateo Sánchez del Pino,

Affiliation Departamento de Bioquímica y Biología Molecular, Universitat de València, Burjassot, Valencia, Spain
⨯
Carla Muñoz-Antoli,

Affiliation Área de Parasitología, Departamento de Biología Celular y Parasitología, Universitat de València, Burjassot, Valencia, Spain
⨯
Rafael Toledo,

Affiliation Área de Parasitología, Departamento de Biología Celular y Parasitología, Universitat de València, Burjassot, Valencia, Spain
⨯
Dolores Bernal

Affiliation Departamento de Bioquímica y Biología Molecular, Universitat de València, Burjassot, Valencia, Spain
⨯

Extracellular Vesicles from Parasitic Helminths Contain Specific Excretory/Secretory Proteins and Are Internalized in Intestinal Host Cells

Antonio Marcilla,
María Trelis,
Alba Cortés,
Javier Sotillo,
Fernando Cantalapiedra,
María Teresa Minguez,
María Luz Valero,
Manuel Mateo Sánchez del Pino,
Carla Muñoz-Antoli,
Rafael Toledo

Published: September 24, 2012
https://doi.org/10.1371/journal.pone.0045974

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Vesicles
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Parasitic intestinal diseases
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Fasciola hepatica
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Exosomes
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Helminths
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Trematodes
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Gastrointestinal tract
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Cytoskeletal proteins
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