Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors

Gustavo Saluste; Maria I. Albarran; Rosa M. Alvarez; Obdulia Rabal; Miguel Angel Ortega; Carmen Blanco; Guido Kurz; Antonio Salgado; Paolo Pevarello; James R. Bischoff; Joaquin Pastor; Julen Oyarzabal

doi:10.1371/journal.pone.0045964

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Open Access

Peer-reviewed

Research Article

Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors

Gustavo Saluste,

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Maria I. Albarran,

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Rosa M. Alvarez,

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Obdulia Rabal,

Current address: Center for Applied Medical Research (CIMA), Small Molecule Discovery Platform, Pamplona, Spain

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Miguel Angel Ortega,

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Carmen Blanco,

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Guido Kurz,

Current address: Oryzon Genomics, Barcelona, Spain

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Antonio Salgado,

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Paolo Pevarello,

Current address: Axxam SpA, Bresso, Italy

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
James R. Bischoff,

Current address: Johnson & Johnson Pharmaceutical R&D, Beerse, Belgium

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Joaquin Pastor,

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯
Julen Oyarzabal

* E-mail: julenoyarzabal@unav.es

Current address: Center for Applied Medical Research (CIMA), Small Molecule Discovery Platform, Pamplona, Spain

Affiliation Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid, Spain
⨯

Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors

Gustavo Saluste,
Maria I. Albarran,
Rosa M. Alvarez,
Obdulia Rabal,
Miguel Angel Ortega,
Carmen Blanco,
Guido Kurz,
Antonio Salgado,
Paolo Pevarello,
James R. Bischoff

Published: October 24, 2012
https://doi.org/10.1371/journal.pone.0045964

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