Transcriptomic and Proteomic Analyses of a Wolbachia-Free Filarial Parasite Provide Evidence of Trans-Kingdom Horizontal Gene Transfer

Samantha N. McNulty; Sahar Abubucker; Gabriel M. Simon; Makedonka Mitreva; Nathan P. McNulty; Kerstin Fischer; Kurt C. Curtis; Norbert W. Brattig; Gary J. Weil; Peter U. Fischer

doi:10.1371/journal.pone.0045777

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Peer-reviewed

Research Article

Transcriptomic and Proteomic Analyses of a Wolbachia-Free Filarial Parasite Provide Evidence of Trans-Kingdom Horizontal Gene Transfer

Samantha N. McNulty ,

* E-mail: smcnulty@wustl.edu

Affiliation Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Sahar Abubucker,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Gabriel M. Simon,

Affiliation Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Makedonka Mitreva,

Affiliations The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Nathan P. McNulty,

Affiliation Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kerstin Fischer,

Affiliation Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kurt C. Curtis,

Affiliation Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Norbert W. Brattig,

Affiliation Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
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Gary J. Weil,

Affiliation Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Peter U. Fischer

Affiliation Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Transcriptomic and Proteomic Analyses of a Wolbachia-Free Filarial Parasite Provide Evidence of Trans-Kingdom Horizontal Gene Transfer

Samantha N. McNulty,
Sahar Abubucker,
Gabriel M. Simon,
Makedonka Mitreva,
Nathan P. McNulty,
Kerstin Fischer,
Kurt C. Curtis,
Norbert W. Brattig,
Gary J. Weil,
Peter U. Fischer

Published: September 26, 2012
https://doi.org/10.1371/journal.pone.0045777

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Wolbachia
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Invertebrate genomics
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Brugia malayi
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Transcriptome analysis
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Onchocerca volvulus
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Protein domains
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BLAST algorithm
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