Salidroside Improves Behavioral and Histological Outcomes and Reduces Apoptosis via PI3K/Akt Signaling after Experimental Traumatic Brain Injury

Szu-Fu Chen; Hsin-Ju Tsai; Tai-Ho Hung; Chien-Cheng Chen; Chao Yu Lee; Chun-Hu Wu; Pei-Yi Wang; Nien-Chieh Liao

doi:10.1371/journal.pone.0045763

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Open Access

Peer-reviewed

Research Article

Salidroside Improves Behavioral and Histological Outcomes and Reduces Apoptosis via PI3K/Akt Signaling after Experimental Traumatic Brain Injury

Szu-Fu Chen ,

* E-mail: szufuchen@yahoo.com.tw

Affiliations Departments of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China, Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China
⨯
Hsin-Ju Tsai,

Affiliations Departments of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China, Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China
⨯
Tai-Ho Hung,

Affiliation Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Taipei and College of Medicine, Chang Gung University, Taipei, Taiwan, Republic of China
⨯
Chien-Cheng Chen,

Affiliation Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China
⨯
Chao Yu Lee,

Affiliation Department of Neuroscience, Institute of Psychiatry, King’s College London, London, United Kingdom
⨯
Chun-Hu Wu,

Affiliations Departments of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China, Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China
⨯
Pei-Yi Wang,

Affiliation Departments of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China
⨯
Nien-Chieh Liao

Affiliation Department of Clinical Pathology, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China
⨯

Salidroside Improves Behavioral and Histological Outcomes and Reduces Apoptosis via PI3K/Akt Signaling after Experimental Traumatic Brain Injury

Szu-Fu Chen,
Hsin-Ju Tsai,
Tai-Ho Hung,
Chien-Cheng Chen,
Chao Yu Lee,
Chun-Hu Wu,
Pei-Yi Wang,
Nien-Chieh Liao

Published: September 24, 2012
https://doi.org/10.1371/journal.pone.0045763

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Apoptosis
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Brain damage
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Mitochondria
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Traumatic brain injury
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Neurons
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Edema
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Histology
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Apoptotic signaling cascade
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