Herpes Simplex Virus 1 ICP22 Inhibits the Transcription of Viral Gene Promoters by Binding to and Blocking the Recruitment of P-TEFb

Lei Guo; Wen-juan Wu; Long-ding Liu; Li-chun Wang; Ying Zhang; Lian-qiu Wu; Ying Guan; Qi-han Li

doi:10.1371/journal.pone.0045749

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Peer-reviewed

Research Article

Herpes Simplex Virus 1 ICP22 Inhibits the Transcription of Viral Gene Promoters by Binding to and Blocking the Recruitment of P-TEFb

Lei Guo ,

Contributed equally to this work with: Lei Guo, Wen-juan Wu

Affiliation Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, People's Republic of China
⨯
Wen-juan Wu ,

Contributed equally to this work with: Lei Guo, Wen-juan Wu

Affiliations Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, People's Republic of China, The First Affilliated Hospital of Kunming Medical College, Kunming, People's Republic of China
⨯
Long-ding Liu,

Affiliation Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, People's Republic of China
⨯
Li-chun Wang,

Affiliation Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, People's Republic of China
⨯
Ying Zhang,

Affiliation Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, People's Republic of China
⨯
Lian-qiu Wu,

Affiliation Institute of Materia Medica, Chinese Academy of Medicine Science, Peking Union Medical College, Beijing, People's Republic of China
⨯
Ying Guan,

Affiliation Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, People's Republic of China
⨯
Qi-han Li

* E-mail: imbcams.lq@gmail.com

Affiliation Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, People's Republic of China
⨯

Herpes Simplex Virus 1 ICP22 Inhibits the Transcription of Viral Gene Promoters by Binding to and Blocking the Recruitment of P-TEFb

Lei Guo,
Wen-juan Wu,
Long-ding Liu,
Li-chun Wang,
Ying Zhang,
Lian-qiu Wu,
Ying Guan,
Qi-han Li

Published: September 24, 2012
https://doi.org/10.1371/journal.pone.0045749

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Plasmid construction
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DNA transcription
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Transcriptional control
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Immunoprecipitation
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Small interfering RNA
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Promoter regions
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Transfection
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Co-immunoprecipitation
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