Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions

Diego Villar; Amaya Ortiz-Barahona; Laura Gómez-Maldonado; Nuria Pescador; Fátima Sánchez-Cabo; Hubert Hackl; Benjamin A. T. Rodriguez; Zlatko Trajanoski; Ana Dopazo; Tim H. M. Huang; Pearlly S. Yan; Luis del Peso

doi:10.1371/journal.pone.0045708

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Open Access

Peer-reviewed

Research Article

Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions

Diego Villar ,

* E-mail: dvillar@iib.uam.es

Current address: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom

Affiliation Department of Biochemistry, Universidad Autónoma de Madrid and Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
⨯
Amaya Ortiz-Barahona,

Affiliation Department of Biochemistry, Universidad Autónoma de Madrid and Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
⨯
Laura Gómez-Maldonado,

Affiliation Department of Biochemistry, Universidad Autónoma de Madrid and Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
⨯
Nuria Pescador,

Affiliation Department of Biochemistry, Universidad Autónoma de Madrid and Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
⨯
Fátima Sánchez-Cabo,

Affiliation Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Hubert Hackl,

Affiliation Biocenter, Division of Bioinformatics, Innsbruck Medical University, Innsbruck, Austria
⨯
Benjamin A. T. Rodriguez,

Affiliation Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
⨯
Zlatko Trajanoski,

Affiliation Biocenter, Division of Bioinformatics, Innsbruck Medical University, Innsbruck, Austria
⨯
Ana Dopazo,

Affiliation Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Tim H. M. Huang,

Affiliation Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
⨯
Pearlly S. Yan,

Affiliation Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
⨯
Luis del Peso

Affiliation Department of Biochemistry, Universidad Autónoma de Madrid and Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
⨯

Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions

Diego Villar,
Amaya Ortiz-Barahona,
Laura Gómez-Maldonado,
Nuria Pescador,
Fátima Sánchez-Cabo,
Hubert Hackl,
Benjamin A. T. Rodriguez,
Zlatko Trajanoski,
Ana Dopazo,
Tim H. M. Huang

Published: September 24, 2012
https://doi.org/10.1371/journal.pone.0045708

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Hypoxia
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Transcription factors
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DNA transcription
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Cell binding
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Binding analysis
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Sequence motif analysis
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Gene expression
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Medical hypoxia
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