Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

Sellamuthu S. Gounder; Sankaranarayanan Kannan; Dinesh Devadoss; Corey J. Miller; Kevin S. Whitehead; Shannon J. Odelberg; Matthew A. Firpo; Robert Paine III; John R. Hoidal; E. Dale Abel; Namakkal S. Rajasekaran

doi:10.1371/journal.pone.0045697

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Open Access

Peer-reviewed

Research Article

Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

Sellamuthu S. Gounder,

Affiliation Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
Sankaranarayanan Kannan,

Affiliation Department of Pediatric Research, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Dinesh Devadoss,

Affiliation Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
Corey J. Miller,

Affiliation Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
Kevin S. Whitehead,

Affiliation Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
Shannon J. Odelberg,

Affiliation Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
Matthew A. Firpo,

Affiliation Department of General Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
Robert Paine III,

Affiliation Division of Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
John R. Hoidal,

Affiliation Division of Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
E. Dale Abel,

Affiliation Division of Endocrinology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯
Namakkal S. Rajasekaran

* E-mail: Raj.Soorappan@hsc.utah.edu

Affiliation Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
⨯

Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

Sellamuthu S. Gounder,
Sankaranarayanan Kannan,
Dinesh Devadoss,
Corey J. Miller,
Kevin S. Whitehead,
Shannon J. Odelberg,
Matthew A. Firpo,
Robert Paine III,
John R. Hoidal,
E. Dale Abel

Published: September 24, 2012
https://doi.org/10.1371/journal.pone.0045697

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Heart
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Aging
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