Silencing of miR-370 in Human Cholangiocarcinoma by Allelic Loss and Interleukin-6 Induced Maternal to Paternal Epigenotype Switch

Fangmei An; Sumitaka Yamanaka; Sarah Allen; Lewis R. Roberts; Gregory J. Gores; Timothy M. Pawlik; Qing Xie; Masaharu Ishida; Esteban Mezey; Anne C. Ferguson-Smith; Yuriko Mori; Florin M. Selaru

doi:10.1371/journal.pone.0045606

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Open Access

Peer-reviewed

Research Article

Silencing of miR-370 in Human Cholangiocarcinoma by Allelic Loss and Interleukin-6 Induced Maternal to Paternal Epigenotype Switch

Fangmei An,

Affiliations Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States of America, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, Department of Gastroenterology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China
⨯
Sumitaka Yamanaka,

Affiliation Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States of America
⨯
Sarah Allen,

Affiliation Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
⨯
Lewis R. Roberts,

Affiliation Divisions of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Gregory J. Gores,

Affiliation Divisions of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Timothy M. Pawlik,

Affiliation Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States of America
⨯
Qing Xie,

Affiliation Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
⨯
Masaharu Ishida,

Affiliation Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States of America
⨯
Esteban Mezey,

Affiliation Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States of America
⨯
Anne C. Ferguson-Smith,

Affiliation Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
⨯
Yuriko Mori,

Affiliation Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States of America
⨯
Florin M. Selaru

* E-mail: fselaru1@jhmi.edu

Affiliation Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States of America
⨯

Silencing of miR-370 in Human Cholangiocarcinoma by Allelic Loss and Interleukin-6 Induced Maternal to Paternal Epigenotype Switch

Fangmei An,
Sumitaka Yamanaka,
Sarah Allen,
Lewis R. Roberts,
Gregory J. Gores,
Timothy M. Pawlik,
Qing Xie,
Masaharu Ishida,
Esteban Mezey,
Anne C. Ferguson-Smith

Published: October 22, 2012
https://doi.org/10.1371/journal.pone.0045606

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