Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice

Tracy L. Adair-Kirk; Gail L. Griffin; Michelle J. Meyer; Diane G. Kelley; Jeffrey H. Miner; Douglas R. Keene; M. Peter Marinkovich; J. Michael Ruppert; Jouni Uitto; Robert M. Senior

doi:10.1371/journal.pone.0045546

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Peer-reviewed

Research Article

Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice

Tracy L. Adair-Kirk ,

* E-mail: tkirk@dom.wustl.edu

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Gail L. Griffin,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Michelle J. Meyer,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Diane G. Kelley,

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jeffrey H. Miner,

Affiliations Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Douglas R. Keene,

Affiliation Department of Molecular and Medical Genetics, Shriners Hospitals for Children, Portland, Oregon, United States of America
⨯
M. Peter Marinkovich,

Affiliation Department of Dermatology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
J. Michael Ruppert,

Affiliation Department of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia, United States of America
⨯
Jouni Uitto,

Affiliation Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America
⨯
Robert M. Senior

Affiliations Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice

Tracy L. Adair-Kirk,
Gail L. Griffin,
Michelle J. Meyer,
Diane G. Kelley,
Jeffrey H. Miner,
Douglas R. Keene,
M. Peter Marinkovich,
J. Michael Ruppert,
Jouni Uitto,
Robert M. Senior

Published: September 18, 2012
https://doi.org/10.1371/journal.pone.0045546

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Genetically modified animals
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Mouse models
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Keratinocytes
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Epidermis
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Immunofluorescence
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Blisters
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Integrins
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