Standardization of the Teratoma Assay for Analysis of Pluripotency of Human ES Cells and Biosafety of Their Differentiated Progeny

Michal Gropp; Vitali Shilo; Gilad Vainer; Miri Gov; Yaniv Gil; Hanita Khaner; Limor Matzrafi; Maria Idelson; Juri Kopolovic; Naomi B. Zak; Benjamin E. Reubinoff

doi:10.1371/journal.pone.0045532

Loading metrics

Open Access

Peer-reviewed

Research Article

Standardization of the Teratoma Assay for Analysis of Pluripotency of Human ES Cells and Biosafety of Their Differentiated Progeny

Michal Gropp ,

Contributed equally to this work with: Michal Gropp, Vitali Shilo

Affiliation The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⨯
Vitali Shilo ,

Contributed equally to this work with: Michal Gropp, Vitali Shilo

Affiliation CellCure NeuroSciences Ltd., Jerusalem, Israel
⨯
Gilad Vainer,

Affiliation The Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⨯
Miri Gov,

Affiliation CellCure NeuroSciences Ltd., Jerusalem, Israel
⨯
Yaniv Gil,

Affiliation The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⨯
Hanita Khaner,

Affiliation The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⨯
Limor Matzrafi,

Affiliation CellCure NeuroSciences Ltd., Jerusalem, Israel
⨯
Maria Idelson,

Affiliation The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⨯
Juri Kopolovic,

Affiliation The Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⨯
Naomi B. Zak,

Affiliation CellCure NeuroSciences Ltd., Jerusalem, Israel
⨯
Benjamin E. Reubinoff

* E-mail: benjaminr@ekmd.hugi.ac.il

Affiliation The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⨯

Standardization of the Teratoma Assay for Analysis of Pluripotency of Human ES Cells and Biosafety of Their Differentiated Progeny

Michal Gropp,
Vitali Shilo,
Gilad Vainer,
Miri Gov,
Yaniv Gil,
Hanita Khaner,
Limor Matzrafi,
Maria Idelson,
Juri Kopolovic,
Naomi B. Zak

Published: September 25, 2012
https://doi.org/10.1371/journal.pone.0045532

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Teratoma
Is the Subject Area "Teratoma" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Pluripotency
Is the Subject Area "Pluripotency" applicable to this article?

Thanks for your feedback.
Stem cell transplantation
Is the Subject Area "Stem cell transplantation" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Histology
Is the Subject Area "Histology" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Stem cells
Is the Subject Area "Stem cells" applicable to this article?

Thanks for your feedback.