Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1G93A Mice However Both Conditions Induce Cellular Changes

Open Access

Peer-reviewed

Research Article

Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1^G93A Mice However Both Conditions Induce Cellular Changes

Yannick N. Gerber ,

Contributed equally to this work with: Yannick N. Gerber, Jean-Charles Sabourin

Affiliations INSERM U1051, Institute for Neurosciences of Montpellier, Pathologies Sensorielles, Neuroplasticité et Thérapies, Saint-Eloi Hospital, Montpellier, France, IKERBASQUE Basque Foundation for Science, Bilbao, Spain
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Jean-Charles Sabourin ,

Contributed equally to this work with: Yannick N. Gerber, Jean-Charles Sabourin

Affiliation Integrative Biology of Neurodegeneration, Neuroscience Department, University of the Basque Country UPV/EHU, Bilbao, Spain
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Jean-Philippe Hugnot,

Affiliation INSERM U1051, Institute for Neurosciences of Montpellier, Pathologies Sensorielles, Neuroplasticité et Thérapies, Saint-Eloi Hospital, Montpellier, France
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Florence E. Perrin

* E-mail: f.perrin@ikerbasque.org

Affiliations INSERM U1051, Institute for Neurosciences of Montpellier, Pathologies Sensorielles, Neuroplasticité et Thérapies, Saint-Eloi Hospital, Montpellier, France, IKERBASQUE Basque Foundation for Science, Bilbao, Spain, Integrative Biology of Neurodegeneration, Neuroscience Department, University of the Basque Country UPV/EHU, Bilbao, Spain
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Sedentary behavior
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Mouse models
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Amyotrophic lateral sclerosis
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Exercise
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Microglial cells
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Spinal cord
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Astrocytes
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Neuromuscular junctions
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