High Prevalence of Posterior Polymorphous Corneal Dystrophy in the Czech Republic; Linkage Disequilibrium Mapping and Dating an Ancestral Mutation

Petra Liskova; Rhian Gwilliam; Martin Filipec; Katerina Jirsova; Stanislava Reinstein Merjava; Panos Deloukas; Tom R. Webb; Shomi S. Bhattacharya; Neil D. Ebenezer; Alex G. Morris; Alison J. Hardcastle

doi:10.1371/journal.pone.0045495

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Peer-reviewed

Research Article

High Prevalence of Posterior Polymorphous Corneal Dystrophy in the Czech Republic; Linkage Disequilibrium Mapping and Dating an Ancestral Mutation

Petra Liskova ,

Contributed equally to this work with: Petra Liskova, Rhian Gwilliam

* E-mail: petra.liskova@lf1.cuni.cz

Affiliations Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Diseases, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic, Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic, UCL Institute of Ophthalmology, London, United Kingdom
⨯
Rhian Gwilliam ,

Contributed equally to this work with: Petra Liskova, Rhian Gwilliam

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Martin Filipec,

Affiliation European Eye Clinic Lexum, Prague, Czech Republic
⨯
Katerina Jirsova,

Affiliation Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Diseases, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
⨯
Stanislava Reinstein Merjava,

Affiliation Laboratory of the Biology and Pathology of the Eye, Institute of Inherited Metabolic Diseases, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
⨯
Panos Deloukas,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Tom R. Webb,

Affiliation UCL Institute of Ophthalmology, London, United Kingdom
⨯
Shomi S. Bhattacharya,

Affiliation UCL Institute of Ophthalmology, London, United Kingdom
⨯
Neil D. Ebenezer,

Affiliation UCL Institute of Ophthalmology, London, United Kingdom
⨯
Alex G. Morris,

Affiliation Division of Brain Sciences, Hammersmith Hospital, Imperial College, London, United Kingdom
⨯
Alison J. Hardcastle

Affiliation UCL Institute of Ophthalmology, London, United Kingdom
⨯

High Prevalence of Posterior Polymorphous Corneal Dystrophy in the Czech Republic; Linkage Disequilibrium Mapping and Dating an Ancestral Mutation

Petra Liskova,
Rhian Gwilliam,
Martin Filipec,
Katerina Jirsova,
Stanislava Reinstein Merjava,
Panos Deloukas,
Tom R. Webb,
Shomi S. Bhattacharya,
Neil D. Ebenezer,
Alex G. Morris

Published: September 25, 2012
https://doi.org/10.1371/journal.pone.0045495

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