In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities

Oscar M. Pello; Raphael Chèvre; Damya Laoui; Alba De Juan; Fidel Lolo; María Jesús Andrés-Manzano; Manuel Serrano; Jo A. Van Ginderachter; Vicente Andrés

doi:10.1371/journal.pone.0045399

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Peer-reviewed

Research Article

In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities

Oscar M. Pello,

Affiliation Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
⨯
Raphael Chèvre ,

Contributed equally to this work with: Raphael Chèvre, Damya Laoui

Affiliation Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
⨯
Damya Laoui ,

Contributed equally to this work with: Raphael Chèvre, Damya Laoui

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel. Brussels, Belgium, Myeloid Cell Immunology Laboratory, VIB, Brussels, Belgium
⨯
Alba De Juan,

Affiliation Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
⨯
Fidel Lolo,

Affiliation Spanish National Cancer Research Center (CNIO), Madrid, Spain
⨯
María Jesús Andrés-Manzano,

Affiliation Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
⨯
Manuel Serrano,

Affiliation Spanish National Cancer Research Center (CNIO), Madrid, Spain
⨯
Jo A. Van Ginderachter,

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel. Brussels, Belgium, Myeloid Cell Immunology Laboratory, VIB, Brussels, Belgium
⨯
Vicente Andrés

* E-mail: vandres@cnic.es

Affiliation Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
⨯

In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities

Oscar M. Pello,
Raphael Chèvre,
Damya Laoui,
Alba De Juan,
Fidel Lolo,
María Jesús Andrés-Manzano,
Manuel Serrano,
Jo A. Van Ginderachter,
Vicente Andrés

Published: September 20, 2012
https://doi.org/10.1371/journal.pone.0045399

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