A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer

• Marina Antelo,

  Affiliation Oncology and Pathology Sections, Hospital of Gastroenterology “Dr. C. B. Udaondo”, Buenos Aires, Argentina

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• Francesc Balaguer ,

  * E-mail: ajay.goel@baylorhealth.edu (AG); fprunes@clinic.ub.es (FB)

  Affiliations Department of Internal Medicine, Division of Gastroenterology, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America, Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain

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• Jinru Shia,

  Affiliation Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

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• Yan Shen,

  Affiliation Department of Internal Medicine, Division of Gastroenterology, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America

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• Keun Hur,

  Affiliation Department of Internal Medicine, Division of Gastroenterology, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America

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• Leticia Moreira,

  Affiliation Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain

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• Miriam Cuatrecasas,

  Affiliation Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain

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• Luis Bujanda,

  Affiliation Department of Gastroenterology, CIBERehd, University of Country Basque, Donostia Hospital, San Sebastián, Spain

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• Maria Dolores Giraldez,

  Affiliation Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain

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• Masanobu Takahashi,

  Affiliation Department of Internal Medicine, Division of Gastroenterology, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America

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• Ana Cabanne,

  Affiliation Oncology and Pathology Sections, Hospital of Gastroenterology “Dr. C. B. Udaondo”, Buenos Aires, Argentina

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• Mario Edmundo Barugel,

  Affiliation Oncology and Pathology Sections, Hospital of Gastroenterology “Dr. C. B. Udaondo”, Buenos Aires, Argentina

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• Mildred Arnold,

  Affiliation Department of Internal Medicine, Division of Gastroenterology, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America

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• Enrique Luis Roca,

  Affiliation Oncology and Pathology Sections, Hospital of Gastroenterology “Dr. C. B. Udaondo”, Buenos Aires, Argentina

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• Montserrat Andreu,

  Affiliation Deparment of Gastroenterology, Hospital del Mar, Barcelona, Spain

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• Sergi Castellvi-Bel,

  Affiliation Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain

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• Xavier Llor,

  Affiliation Department of Medicine and Cancer Center, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Rodrigo Jover,

  Affiliation Gastroenterology Unit, Hospital General Universitario, Alicante, Spain

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• Antoni Castells,

  Affiliation Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain

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• C. Richard Boland,

  Affiliation Department of Internal Medicine, Division of Gastroenterology, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America

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•  [ ... ],
• Ajay Goel

  * E-mail: ajay.goel@baylorhealth.edu (AG); fprunes@clinic.ub.es (FB)

  Affiliation Department of Internal Medicine, Division of Gastroenterology, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, United States of America

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