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Open Access
Peer-reviewed
Research Article
Genetic Inhibition of CaMKII in Dorsal Striatal Medium Spiny Neurons Reduces Functional Excitatory Synapses and Enhances Intrinsic Excitability
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Jason R. Klug,
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Brian N. Mathur,
Affiliation Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America
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Thomas L. Kash,
Current address: Bowles Center for Alcohol Studies, Department of Pharmacology, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Hui-Dong Wang,
Affiliation Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Robert T. Matthews,
Affiliations Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, J.F. Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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A. J. Robison,
Current address: Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America
Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Mark E. Anderson,
Affiliation Departments of Internal Medicine and Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, United States of America
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Ariel Y. Deutch,
Affiliations Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, J.F. Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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David M. Lovinger,
Affiliation Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America
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Roger J. Colbran,
Affiliations Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, J.F. Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Danny G. Winder
* E-mail: danny.winder@vanderbilt.edu
Affiliations Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, J.F. Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Genetic Inhibition of CaMKII in Dorsal Striatal Medium Spiny Neurons Reduces Functional Excitatory Synapses and Enhances Intrinsic Excitability
- Jason R. Klug,
- Brian N. Mathur,
- Thomas L. Kash,
- Hui-Dong Wang,
- Robert T. Matthews,
- A. J. Robison,
- Mark E. Anderson,
- Ariel Y. Deutch,
- David M. Lovinger,
- Roger J. Colbran
- Published: September 21, 2012
- https://doi.org/10.1371/journal.pone.0045323