Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α5β1 and ERK-Dependent Signaling Pathways

Douglas N. Clarke; Abraham Al Ahmad; Boyeon Lee; Christi Parham; Lisa Auckland; Andrezj Fertala; Michael Kahle; Courtney S. Shaw; Jill Roberts; Gregory J. Bix

doi:10.1371/journal.pone.0045257

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Peer-reviewed

Research Article

Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α₅β₁ and ERK-Dependent Signaling Pathways

Douglas N. Clarke,

Affiliations Department of Molecular & Cellular Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America, Center for Vascular Biology Research, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Abraham Al Ahmad,

Affiliation Department of Molecular & Cellular Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America
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Boyeon Lee,

Affiliation Department of Molecular & Cellular Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America
⨯
Christi Parham,

Affiliation Department of Molecular & Cellular Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America
⨯
Lisa Auckland,

Affiliation Department of Molecular & Cellular Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America
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Andrezj Fertala,

Affiliation Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Michael Kahle,

Affiliations Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, College Station, Texas, United States of America, Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, and Department of Neurology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Courtney S. Shaw,

Affiliation Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, College Station, Texas, United States of America
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Jill Roberts,

Affiliation Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, and Department of Neurology, University of Kentucky, Lexington, Kentucky, United States of America
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Gregory J. Bix

* E-mail: gregorybix@uky.edu

Affiliation Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, and Department of Neurology, University of Kentucky, Lexington, Kentucky, United States of America
⨯

Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α₅β₁ and ERK-Dependent Signaling Pathways

Douglas N. Clarke,
Abraham Al Ahmad,
Boyeon Lee,
Christi Parham,
Lisa Auckland,
Andrezj Fertala,
Michael Kahle,
Courtney S. Shaw,
Jill Roberts,
Gregory J. Bix

Published: September 17, 2012
https://doi.org/10.1371/journal.pone.0045257

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Integrins
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Endothelial cells
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Secretion
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ERK signaling cascade
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Neurons
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Angiogenesis
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Immunoblotting
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