A Conserved Motif in the ITK PH-Domain Is Required for Phosphoinositide Binding and TCR Signaling but Dispensable for Adaptor Protein Interactions

• Nupura Hirve ,

  Contributed equally to this work with: Nupura Hirve, Roman M. Levytskyy

  Affiliation Molecular Biology Institute and Center for Microbial Sciences, Department of Biology, San Diego State University, San Diego, California, United States of America

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• Roman M. Levytskyy ,

  Contributed equally to this work with: Nupura Hirve, Roman M. Levytskyy

  Affiliation Molecular Biology Institute and Center for Microbial Sciences, Department of Biology, San Diego State University, San Diego, California, United States of America

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• Stephanie Rigaud,

  Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• David M. Guimond,

  Affiliation Molecular Biology Institute and Center for Microbial Sciences, Department of Biology, San Diego State University, San Diego, California, United States of America

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• Tomasz Zal,

  Affiliation MD Anderson Cancer Center, Department of Immunology, The University of Texas, Houston, Texas, United States of America

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• Karsten Sauer,

  Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Constantine D. Tsoukas

  * E-mail: ctsoukas@sciences.sdsu.edu

  Affiliation Molecular Biology Institute and Center for Microbial Sciences, Department of Biology, San Diego State University, San Diego, California, United States of America

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