The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

Dan-Dan Li; Ting Sun; Xiao-Qi Wu; Shu-Peng Chen; Rong Deng; Shan Jiang; Gong-Kan Feng; Jing-Xuan Pan; Xiao-Shi Zhang; Yi-Xin Zeng; Xiao-Feng Zhu

doi:10.1371/journal.pone.0045058

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Open Access

Peer-reviewed

Research Article

The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

Dan-Dan Li,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Ting Sun,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Xiao-Qi Wu,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Shu-Peng Chen,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Rong Deng,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Shan Jiang,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Gong-Kan Feng,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Jing-Xuan Pan,

Affiliation Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Xiao-Shi Zhang,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Yi-Xin Zeng,

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Xiao-Feng Zhu

* E-mail: zhuxfeng@mail.sysu.edu.cn

Affiliation State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
⨯

The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

Dan-Dan Li,
Ting Sun,
Xiao-Qi Wu,
Shu-Peng Chen,
Rong Deng,
Shan Jiang,
Gong-Kan Feng,
Jing-Xuan Pan,
Xiao-Shi Zhang,
Yi-Xin Zeng

Published: September 14, 2012
https://doi.org/10.1371/journal.pone.0045058

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