The Conserved Residue Arg46 in the N-Terminal Heptad Repeat Domain of HIV-1 gp41 Is Critical for Viral Fusion and Entry

• Xiaoyi Wang ,

  Contributed equally to this work with: Xiaoyi Wang, Weiliang Xiong, Xiaochu Ma

  Affiliation Key Laboratory of Tropical Disease Control of MOE, Department of Biochemistry and The Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

  ⨯
• Weiliang Xiong ,

  Contributed equally to this work with: Xiaoyi Wang, Weiliang Xiong, Xiaochu Ma

  Affiliation Key Laboratory of Tropical Disease Control of MOE, Department of Biochemistry and The Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

  ⨯
• Xiaochu Ma ,

  Contributed equally to this work with: Xiaoyi Wang, Weiliang Xiong, Xiaochu Ma

  Affiliation Key Laboratory of Tropical Disease Control of MOE, Department of Biochemistry and The Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

  ⨯
• Meili Wei,

  Affiliation Key Laboratory of Tropical Disease Control of MOE, Department of Biochemistry and The Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

  ⨯
• Yanxia Chen,

  Affiliation Key Laboratory of Tropical Disease Control of MOE, Department of Biochemistry and The Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

  ⨯
• Lu Lu,

  Affiliations Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America

  ⨯
• Asim K. Debnath,

  Affiliation Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America

  ⨯
• Shibo Jiang ,

  * E-mail: Shibojiang@fudan.edu.cn (SJ); Panchung@mail.sysu.edu.cn (CP)

  Affiliations Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America

  ⨯
• Chungen Pan

  * E-mail: Shibojiang@fudan.edu.cn (SJ); Panchung@mail.sysu.edu.cn (CP)

  Affiliation Key Laboratory of Tropical Disease Control of MOE, Department of Biochemistry and The Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

  ⨯