Role of Ca2+ in the Control of H2O2-Modulated Phosphorylation Pathways Leading to eNOS Activation in Cardiac Myocytes

Open Access

Peer-reviewed

Research Article

Role of Ca²⁺ in the Control of H₂O₂-Modulated Phosphorylation Pathways Leading to eNOS Activation in Cardiac Myocytes

Juliano L. Sartoretto ,

Contributed equally to this work with: Juliano L. Sartoretto, Hermann Kalwa

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Hermann Kalwa ,

Contributed equally to this work with: Juliano L. Sartoretto, Hermann Kalwa

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Takashi Shiroto,

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Simone M. Sartoretto,

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Michael D. Pluth,

Affiliation Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Stephen J. Lippard,

Affiliation Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Thomas Michel

* E-mail: thomas_michel@harvard.edu

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Muscle cells
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Phosphorylation
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Immunoblotting
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Protein kinases
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Hydrogen peroxide
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Fluorescence imaging
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Nitric oxide
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Sarcomeres
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