Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population

Natsuhiko Kumasaka; Masayuki Aoki; Yukinori Okada; Atsushi Takahashi; Kouichi Ozaki; Taisei Mushiroda; Tomomitsu Hirota; Mayumi Tamari; Toshihiro Tanaka; Yusuke Nakamura; Naoyuki Kamatani; Michiaki Kubo

doi:10.1371/journal.pone.0044507

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Open Access

Peer-reviewed

Research Article

Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population

Natsuhiko Kumasaka,

Affiliation Research Group for Medical Informatics, Center for Genomic Medicine, RIKEN, Tokyo, Japan
⨯
Masayuki Aoki,

Affiliation Research Group for Genotyping, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯
Yukinori Okada,

Affiliation Research Group for Medical Informatics, Center for Genomic Medicine, RIKEN, Tokyo, Japan
⨯
Atsushi Takahashi,

Affiliation Research Group for Medical Informatics, Center for Genomic Medicine, RIKEN, Tokyo, Japan
⨯
Kouichi Ozaki,

Affiliation Research Group for Disease-causing Mechanism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯
Taisei Mushiroda,

Affiliation Research Group for Pharmacogenomics, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯
Tomomitsu Hirota,

Affiliation Research Group for Disease-causing Mechanism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯
Mayumi Tamari,

Affiliation Research Group for Disease-causing Mechanism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯
Toshihiro Tanaka,

Affiliation Research Group for Disease-causing Mechanism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯
Yusuke Nakamura,

Affiliation Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯
Naoyuki Kamatani,

Affiliation Research Group for Pharmacogenomics, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯
Michiaki Kubo

* E-mail: mkubo@src.riken.jp

Affiliation Research Group for Genotyping, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
⨯

Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population

Natsuhiko Kumasaka,
Masayuki Aoki,
Yukinori Okada,
Atsushi Takahashi,
Kouichi Ozaki,
Taisei Mushiroda,
Tomomitsu Hirota,
Mayumi Tamari,
Toshihiro Tanaka,
Yusuke Nakamura

Published: September 25, 2012
https://doi.org/10.1371/journal.pone.0044507

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Genome-wide association studies
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Single nucleotide polymorphisms
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Haplotypes
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Variant genotypes
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