Nicorandil Prevents Right Ventricular Remodeling by Inhibiting Apoptosis and Lowering Pressure Overload in Rats with Pulmonary Arterial Hypertension

Xiang-Rong Zuo; Qiang Wang; Quan Cao; Yan-Zhe Yu; Hui Wang; Li-Qing Bi; Wei-Ping Xie; Hong Wang

doi:10.1371/journal.pone.0044485

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Open Access

Peer-reviewed

Research Article

Nicorandil Prevents Right Ventricular Remodeling by Inhibiting Apoptosis and Lowering Pressure Overload in Rats with Pulmonary Arterial Hypertension

Xiang-Rong Zuo ,

Contributed equally to this work with: Xiang-Rong Zuo, Qiang Wang, Quan Cao

Affiliations Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China, Department of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Qiang Wang ,

Contributed equally to this work with: Xiang-Rong Zuo, Qiang Wang, Quan Cao

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Quan Cao ,

Contributed equally to this work with: Xiang-Rong Zuo, Qiang Wang, Quan Cao

Affiliation Department of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Yan-Zhe Yu,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Hui Wang,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Li-Qing Bi,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Wei-Ping Xie ,

* E-mail: wanghong.njmu@gmail.com (HW); xieweiping2002@yahoo.com (WX)

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Hong Wang

* E-mail: wanghong.njmu@gmail.com (HW); xieweiping2002@yahoo.com (WX)

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯

Nicorandil Prevents Right Ventricular Remodeling by Inhibiting Apoptosis and Lowering Pressure Overload in Rats with Pulmonary Arterial Hypertension

Xiang-Rong Zuo,
Qiang Wang,
Quan Cao,
Yan-Zhe Yu,
Hui Wang,
Li-Qing Bi,
Wei-Ping Xie,
Hong Wang

Published: September 7, 2012
https://doi.org/10.1371/journal.pone.0044485

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Apoptosis
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Cardiomyocytes
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Mitochondria
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Fibrosis
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Muscle cells
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Pulmonary hypertension
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