Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging

David Marcellin; Dorothee Abramowski; Douglas Young; Jens Richter; Andreas Weiss; Audrey Marcel; Julia Maassen; Muriel Kauffmann; Miriam Bibel; Derya R. Shimshek; Richard L. M. Faull; Gillian P. Bates; Rainer R. Kuhn; P. Herman Van der Putten; Peter Schmid; Gregor P. Lotz

doi:10.1371/journal.pone.0044457

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Peer-reviewed

Research Article

Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging

David Marcellin,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Dorothee Abramowski,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Douglas Young,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Jens Richter,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Andreas Weiss,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Audrey Marcel,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Julia Maassen,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Muriel Kauffmann,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Miriam Bibel,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Derya R. Shimshek,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Richard L. M. Faull,

Affiliation Centre for Brain Research, Auckland University, Auckland, New Zealand
⨯
Gillian P. Bates,

Affiliation Department of Medical and Molecular Genetics, King’s College London, London, United Kingdom
⨯
Rainer R. Kuhn,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
P. Herman Van der Putten,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
Peter Schmid,

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
[ ... ],
Gregor P. Lotz

* E-mail: gregor.lotz@novartis.com

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⨯
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Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging

David Marcellin,
Dorothee Abramowski,
Douglas Young,
Jens Richter,
Andreas Weiss,
Audrey Marcel,
Julia Maassen,
Muriel Kauffmann,
Miriam Bibel,
Derya R. Shimshek

Published: September 12, 2012
https://doi.org/10.1371/journal.pone.0044457

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