Monitoring CSF Proteome Alterations in Amyotrophic Lateral Sclerosis: Obstacles and Perspectives in Translating a Novel Marker Panel to the Clinic

Nils von Neuhoff; Tonio Oumeraci; Thomas Wolf; Katja Kollewe; Peter Bewerunge; Boris Neumann; Benedikt Brors; Johannes Bufler; Ulrich Wurster; Brigitte Schlegelberger; Reinhard Dengler; Marc Zapatka; Susanne Petri

doi:10.1371/journal.pone.0044401

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Open Access

Peer-reviewed

Research Article

Monitoring CSF Proteome Alterations in Amyotrophic Lateral Sclerosis: Obstacles and Perspectives in Translating a Novel Marker Panel to the Clinic

Nils von Neuhoff ,

* E-mail: neuhoff.nils.von@mh-hannover.de

Affiliation Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
⨯
Tonio Oumeraci,

Affiliation Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
⨯
Thomas Wolf,

Affiliations Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany, Computational Oncology, Division of Theoretical Bioinformatics, Research Program Structural and Functional Genomics, German Cancer Research Center, INF 580, Heidelberg, Germany
⨯
Katja Kollewe,

Affiliation Department of Neurology, Hannover Medical School, Hannover, Germany
⨯
Peter Bewerunge,

Affiliation Computational Oncology, Division of Theoretical Bioinformatics, Research Program Structural and Functional Genomics, German Cancer Research Center, INF 580, Heidelberg, Germany
⨯
Boris Neumann,

Affiliation Proteome Factory AG, Berlin, Germany
⨯
Benedikt Brors,

Affiliation Computational Oncology, Division of Theoretical Bioinformatics, Research Program Structural and Functional Genomics, German Cancer Research Center, INF 580, Heidelberg, Germany
⨯
Johannes Bufler,

Affiliation Department of Neurology, Hannover Medical School, Hannover, Germany
⨯
Ulrich Wurster,

Affiliation Department of Neurology, Hannover Medical School, Hannover, Germany
⨯
Brigitte Schlegelberger,

Affiliation Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
⨯
Reinhard Dengler,

Affiliation Department of Neurology, Hannover Medical School, Hannover, Germany
⨯
Marc Zapatka,

Affiliation Computational Oncology, Division of Theoretical Bioinformatics, Research Program Structural and Functional Genomics, German Cancer Research Center, INF 580, Heidelberg, Germany
⨯
Susanne Petri

Affiliation Department of Neurology, Hannover Medical School, Hannover, Germany
⨯

Monitoring CSF Proteome Alterations in Amyotrophic Lateral Sclerosis: Obstacles and Perspectives in Translating a Novel Marker Panel to the Clinic

Nils von Neuhoff,
Tonio Oumeraci,
Thomas Wolf,
Katja Kollewe,
Peter Bewerunge,
Boris Neumann,
Benedikt Brors,
Johannes Bufler,
Ulrich Wurster,
Brigitte Schlegelberger

Published: September 6, 2012
https://doi.org/10.1371/journal.pone.0044401

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Cerebrospinal fluid
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Biomarkers
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Amyotrophic lateral sclerosis
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Nerve growth factor
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Proteomes
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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