Multiple Analyses of G-Protein Coupled Receptor (GPCR) Expression in the Development of Gefitinib-Resistance in Transforming Non-Small-Cell Lung Cancer

Naoko Kuzumaki; Atsuo Suzuki; Michiko Narita; Takahiro Hosoya; Atsumi Nagasawa; Satoshi Imai; Kohei Yamamizu; Hiroshi Morita; Tsutomu Suzuki; Yohei Okada; Hirotaka James Okano; Jun K. Yamashita; Hideyuki Okano; Minoru Narita

doi:10.1371/journal.pone.0044368

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Open Access

Peer-reviewed

Research Article

Multiple Analyses of G-Protein Coupled Receptor (GPCR) Expression in the Development of Gefitinib-Resistance in Transforming Non-Small-Cell Lung Cancer

Naoko Kuzumaki ,

* E-mail: naokokuzumaki@gmail.com (NK); narita@hoshi.ac.jp (Minoru Narita)

Affiliations Department of Physiology, Keio University, School of Medicine, Tokyo, Japan, Department of Pharamacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯
Atsuo Suzuki,

Affiliation Department of Pharamacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯
Michiko Narita,

Affiliation Department of Pharamacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯
Takahiro Hosoya,

Affiliation Biological Systems Control Team, Biomedicinal Information Research Center, Tokyo, Japan
⨯
Atsumi Nagasawa,

Affiliation Department of Pharamacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯
Satoshi Imai,

Affiliation Department of Pharamacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯
Kohei Yamamizu,

Affiliation Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
⨯
Hiroshi Morita,

Affiliation Faculty of Pharmaceutical Sciences, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯
Tsutomu Suzuki,

Affiliation Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯
Yohei Okada,

Affiliation Department of Physiology, Keio University, School of Medicine, Tokyo, Japan
⨯
Hirotaka James Okano,

Affiliation Department of Physiology, Keio University, School of Medicine, Tokyo, Japan
⨯
Jun K. Yamashita,

Affiliation Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
⨯
Hideyuki Okano,

Affiliation Department of Physiology, Keio University, School of Medicine, Tokyo, Japan
⨯
Minoru Narita

* E-mail: naokokuzumaki@gmail.com (NK); narita@hoshi.ac.jp (Minoru Narita)

Affiliation Department of Pharamacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
⨯

Multiple Analyses of G-Protein Coupled Receptor (GPCR) Expression in the Development of Gefitinib-Resistance in Transforming Non-Small-Cell Lung Cancer

Naoko Kuzumaki,
Atsuo Suzuki,
Michiko Narita,
Takahiro Hosoya,
Atsumi Nagasawa,
Satoshi Imai,
Kohei Yamamizu,
Hiroshi Morita,
Tsutomu Suzuki,
Yohei Okada

Published: October 29, 2012
https://doi.org/10.1371/journal.pone.0044368

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G protein coupled receptors
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Non-small cell lung cancer
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Adenosine
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