Characterization of Rheumatoid Arthritis Subtypes Using Symptom Profiles, Clinical Chemistry and Metabolomics Measurements

• Herman A. van Wietmarschen ,

  Contributed equally to this work with: Herman A. van Wietmarschen, Weidong Dai

  * E-mail: h.vanwietmarschen@lacdr.leidenuniv.nl (HvW); xugw@dicp.ac.cn (GX)

  Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands

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• Weidong Dai ,

  Contributed equally to this work with: Herman A. van Wietmarschen, Weidong Dai

  Affiliation CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

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• Anita J. van der Kooij,

  Affiliation Mathematical Institute, Leiden University, Leiden, The Netherlands

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• Theo H. Reijmers,

  Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands

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• Yan Schroën,

  Affiliations Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands, Oxrider, Education and Research, Nieuwegein, The Netherlands

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• Mei Wang,

  Affiliations Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands, SU BioMedicine, Utrechtseweg, Zeist, The Netherlands

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• Zhiliang Xu,

  Affiliation College of Life Science Company Limited, Hangzhou, China

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• Xinchang Wang,

  Affiliation Zhejiang Xinhua hospital Rheumatology and Immunology Department, HangZhou, China

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• Hongwei Kong,

  Affiliation CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

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• Guowang Xu ,

  * E-mail: h.vanwietmarschen@lacdr.leidenuniv.nl (HvW); xugw@dicp.ac.cn (GX)

  Affiliation CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

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• Thomas Hankemeier,

  Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands

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• Jacqueline J. Meulman,

  Affiliation Mathematical Institute, Leiden University, Leiden, The Netherlands

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• Jan van der Greef

  Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands, SU BioMedicine, Utrechtseweg, Zeist, The Netherlands, TNO Netherlands Organization for Applied Scientific Research, TNO Pharma, Zeist, The Netherlands

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